The kits for mutations detection are based on destructible oligonucleotide probes (TaqMan) with chemical modifications of locked nucleic acids. That allows achieving high sensitivity and specificity of the kits. The kits detect up to 1% of mutant DNA with with an accuracy of at least 99,9% in the "one tube" format.
PCR kits for sequencing inclose M13, which can reduce essentially tests labor intensity and perform sequencing under the same conditions for the most of amplicons. PCR kits for restriction and electrophoresis are easy to use and don't require expensive equipment.
Kits for genotyping are identical with TaqMan SNP Genotyping Assays produced by Applied Biosystems. The kits are based on using chemical modification of LNA (locked nucleic acid) and are notable for choice quality of allelic discrimination even in complex sequences. The kits are compatible with all common real-time thermocycler.
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